ノビレチン(ポリメトキシフラボノイド類/フラボノイド)

ノビレチンには、抗がん・抗炎症・肥満抑制・血糖降下作用などの効果について報告されています。文献参照。

 

慣用名

ノビレチン(Nobiletin)

CAS No.

478-01-3

分子式

C21H22O8

M.W.

402.39

シークヮーサー

果皮
mg・gDW-1

未 熟

18.93

適 熟

7.75

カーブチー

未 熟

11.62

適 熟

6.24

オート-

未 熟

2.05

適 熟

1.50

タロガヨ

未 熟

6.42

適 熟

3.76

クネンボ

未 熟

1.38

適 熟

0.57

タンカン

未 熟

14.96

適 熟

9.05

シークヮーサー

果汁
μgmL-1

未 熟

1.32

適 熟

1.24

カーブチー

未 熟

0.20

適 熟

0.89

オート-

未 熟

0.37

適 熟

1.24

タロガヨ

未 熟

0.11

適 熟

0.27

クネンボ

未 熟

0.14

適 熟

0.20

タンカン

未 熟

0.47

適 熟

0.60

主な効能

抗がん・抗炎症・肥満抑制・血糖降下

文献

1,2,5,12,14,15,16,19,20,21,26,27

参考文献

1

Akachi, T., Shiina, Y., Ohishi, Y., Kawaguchi, T., Kawagishi, H., Morita, T., Mori, M. and Sugiyama, K. 2010. Hepatoprotective effects of flavonoids from Shekwasha (Citrus depressa) against D-Galactosamine-induced liver injury in rats. J. Nutr. Vitaminol. 56: 60-67.

2

Akao, Y., Itoh, T., Ohguchi, K. and Nozawa, Y. 2008. Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells. Bioorg. Med. Chem. 16: 2903-2810.

5

Gimenez-Basutida, J-A., Martinez-Florensa, M., Espin, J-C., Tomas-Barneran, F. A. and Garcia-Conesa, M-T. 2009. A citrus extract containing flavanones represses plasminogen activator inhibitor-1 (PAI-1) expression and regulates multiple inflammatory, tissue repair, and fibrosis genes in human colon fibroblasts. J. Agric. Food Chem. 57: 9305-9315.

12

十一元晴 2005. カンキツ類の化学成分とがん予防物質に関する研究. 薬学雑誌. 125: 231-254.

14

Kawaii, S., Tomono, Y., Katase, E., Ogawa, K. and Yano, M. 1999. Antiprofiferative activity of flavonoids on several cancer cell lines. Bioci. Biotechnol. Biochem. 63:896-899.  

15

Kunimasa, K., Kuranuki, S., Matuura, N., Iwasaki, N., Ikeda, M., Ito, A., Sashida, Y., Mimaki, Y., Yano, M., Sato, M., Igarashi, Y. and Oikawa, T. 2009. Identification of nobiletin, a polymethoxyflavonoid, as an enhancer of adiponectin secretion. Bioorgan. Med. Chem. Letters. 19: 2062-2064.

16

Lee, Y-S., Cha, B-Y., Saito, K., Yamakawa, H., Choi, S-S., Yamaguchi, K., Yonezawa, T., Teruya, T., Nagai, K. and Woo, JT. 2010. Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice. Biochem. Parmacol. 79: 1674-83.

19

Miyata, Y., Sato, T., Imada, K., Dobashi, A., Yano, M. and Ito, A. 2008. A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells. Biochem. Biophys. Res. Commun. 366: 168-173.

20

Nakajima, A., Yamakuni, T., Haraguchi, M., Omae, N., Song, S-Y., Kato, C., Nakagawasai, O., Tadano, T., Yokosuka, A., Mimaki, Y., Sashida, Y. and Oizumi Y. 2007. Nobiletin, a citrus flavonoid that improves memory impairment, resucues bulbectomy-induced cholinergic neurodegeneration in mice. J. Pharmacol. Sci. 105: 122-126.

21

Ohtani, H., Ikegawa, T., Honda, Y., Kohyama, N., Morimoto, S., Shoyama, Y., Juichi, M., Naito, M., Tsuruo T. and Sawada, Y. 2007. Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM Cells. Pharm. Res. 24: 1936-1943.

26

Wu, Y-Q., Zhou, C-H., Tao, J. and Li, S-N. 2006. Antagonistic effects of nobiletin, a polymethoxyflavonoid, on eosinophilic airway inflammation of asthmatic rats and relevant mechanisms. Life Sci. 78: 2689-2696.

27

矢野昌充 2003. 果実成分による癌の化学予防(癌の予防最前線). 医学のあゆみ. 医歯薬出版. 東京. 204: 45-49.